Tricyclic antidepressants block N-methyl-d-aspartic acid-induced lethality in mice

N-methyl-D-aspartic acid receptor structure and function.

Paraneoplastic Anti-N-Methyl-D-Aspartic Acid Receptor Encephalitis

N-Hydroxypyrazolyl glycine derivatives as selective N-methyl-D-aspartic acid receptor ligands.

A series of analogues based on N-hydroxypyrazole as a bioisostere for the distal carboxylate group of aspartate have been designed, synthesized, and pharmacologically characterized. Affinity studies on the major glutamate receptor subgroups show that these 4-substituted N-hydroxypyrazol-5-yl glycine (NHP5G) derivatives are selectively recognized by N-methyl- d-aspartic acid (NMDA) receptors and...

Evaluation of Radio-Protective Effects of N-Acetylcysteine on Radiation-Induced Lethality in Mice

Introduction It has long been known that ionizing radiation can lead to detrimental effects in normal cells. In this light, Radioprotective chemicals have been used to decrease morbidity or mortality caused by ionizing irradiation. This study aimed to evaluate the radio-protective effect of N-acetylcysteineagainst radiation-induced mortality in male mice. Materials and Methods 52 healthy mal...

Intracellular calcium concentration changes initiated by N-methyl-D-aspartic acid receptors in retinal horizontal cells.

Intracellular calcium concentration changes initiated by N-methyl-D-aspartic acid receptors were studied in carp retinal horizontal cells. Fura-2 fluorescent calcium imaging showed that H1 subtype horizontal cells responded to exogenously applied N-methyl-D-aspartic acid with a transient intracellular free Ca(2+) ([Ca2+]i) increase that decayed to a sustained, but elevated level of [Ca(2+)]i. C...